GIQuIC Research Overview
GIQuIC Research Policies & Procedures
GIQuIC Research Committee
GIQuIC Publications
Research FAQs


GIQuIC Research Overview

Since 2010, GIQuIC has set the standard in the collection and reporting of quality measures in the practice of gastrointestinal endoscopy. This robust dataset is an invaluable resource for practice benchmarking and further provides an excellent opportunity for those interested in gastroenterology research.

GIQuIC registry data are contributed from endoscopy units in various practice settings across the United States. Data enters the registry via two methods: direct data entry or, more commonly, upload from an endowriter. For the purpose of research, GIQuIC registry data undergoes a de-identification process and is transferred to the Research Data Warehouse. This separate database is stored on a different secure server from the registry data and can only be accessed by GIQuIC staff.

The Research Data warehouse contains de-identified information on sites, providers, and patients and procedures that allows investigators to address complex and varied research questions. For an overview of data included in the registry, please refer to the colonoscopy and EGD data collection forms.

The GIQuIC Research Committee carefully reviews all project proposals, evaluating the project’s feasibility, novelty and potential impact. All analyses are completed by GIQuIC’s team of in-house data analysts, who work closely with Project Investigators in order to best address the research question. Most projects are undertaken with the intention of publishing results in a peer-reviewed journal.

For general research inquiries, contact


GIQuIC Research Policies & Procedures

Our research process generally follows the steps presented below:

  1. Interested investigators contact GIQuIC via to begin the research process. Upon receipt of the initial query, the investigator will be contacted by a GIQuIC Data Analyst to review any preliminary questions and to discuss the feasibility of the proposed project.

    The GIQuIC Data Analyst will furnish the investigator with a research proposal form. This form includes questions regarding the project background/significance, research question and/or hypothesis, and specific aims. Proposals may also include an overview of methodology and statistical analyses. If applicable, a Conflict of Interest form may be required.
  1. Upon receipt of a project proposal form, a GIQuIC Data Analyst will contact the investigators to inform them that the submission has been received and, if necessary, to review any items that require immediate clarification. If necessary, preliminary edits to the proposal may be suggested or requested.
  1. Refined proposals will be presented to the GIQuIC Research Committee on a biannual basis. Among other considerations, proposals are evaluated for feasibility, novelty, potential impact/importance to the GI community, and overlap with other GIQuIC research projects. Only a limited number of research projects will be considered for approval and approved at one time.
  1. Approval will be granted to proposals deemed by the Research Committee to be a strong fit for the Research Data Warehouse’s capabilities. If approved, a scope of work will be drafted and sent to the investigators for their review. This scope of work will include:
    1. Proposal text
    2. Analysis plan, if not included in proposal
    3. Project cost
    4. Contract terms
    5. Signature field for GIQuIC Executive Director and project Principal Investigator.
  1. Once details of the research proposal and scope of work have been agreed upon by both parties, the GIQuIC publication agreement should be signed and submitted to GIQuIC within 14 days.
  1. If applying for grant funding or an abstract deadline, proposals shall be submitted no fewer than 60 days prior to deadline to allow for adequate processing time. GIQuIC will provide a letter of support once the grant submission and the scope of work has been approved.
  1. Upon receipt of the signed scope of work, publication agreement, and a mutually agreed upon payment schedule, a GIQuIC data analyst will initiate the analysis and regularly communicate progress to the Principal Investigator.
  1. If a manuscript has not been submitted to a peer-reviewed journal within 1 year of the receipt of results, the Principal Investigator will transfer his/her rights to the use of those results back to GIQuIC. GIQuIC also reserves the right to prevent a manuscript from consideration for publication if serious concerns are raised regarding the quality or accuracy of the manuscript’s contents.

If at any point during this process it is determined that the GIQuIC Research Data Warehouse is not an appropriate fit for your project, a research staff member will notify you promptly.
If you have any questions about the research process, please see the GIQuIC Research FAQs below or contact GIQuIC Data Analysts here.

GIQuIC Research Committee

Audrey Calderwood, MD, FACG, FASGE • Chair, GIQuIC Research Committee

Dr. Calderwood is an Associate Professor of Medicine at Dartmouth-Hitchcock Medical Center and the Dartmouth Institute for Health Policy and Clinical Practice in Lebanon, NH. Quality has been an overarching theme throughout her career. She is passionate about risk-aligned care, such that high-risk patients receive appropriate and timely care and that low risk patients avoid unnecessary procedures. She validated, disseminated and educated providers on the Boston Bowel Preparation Scale during her NIH Career Development Award. Her current NCI-funded R21 grant to optimize use of surveillance colonoscopy in older adults. At the national level, she has been highly involved in the American Society of Gastrointestinal Endoscopy where she served for six years on the Quality Assurance in Endoscopy Committee. As part of this committee, she co-directed a national course on quality in the endoscopy unit. She has also co-chaired multi-society guidelines on safety in the endoscopy unit and infection control in endoscopy, both of which set the gold standard for the practice of high-quality endoscopy.

Jason Dominitz, MD, MHS, FACG, FASGE

Jason Dominitz, MD, MHS is the National Program Director for Gastroenterology for the US Veterans Health Administration. He completed his undergraduate education at the Johns Hopkins University in Baltimore, Md and received his medical degree from the University of Maryland. He then trained in internal medicine and gastroenterology at Duke University in Durham, NC. Concurrently, he studied health services research and received a master’s degree in Health Sciences from Duke University. Since 1997, Dr. Dominitz has been a staff physician at the VA Puget Sound Health Care System (VAPSHCS) in Seattle, WA and is also a Professor of Medicine at the University of Washington. He has a longstanding interest in colorectal cancer screening and is the co-chair of an 18 year, VA-funded, randomized, prospective trial comparing two leading strategies of colorectal cancer screening in 50,000 average risk Veterans. This study, involving 46 VA medical centers across the US, is the first large-scale, prospective study in the United States comparing screening colonoscopy to a non-invasive fecal immunochemical test and assessing their impact on cancer mortality and incidence. Dr. Dominitz also has received research funding from the NIH and the Department of Defense. In 2011, Dr. Dominitz assumed the role of National Program Director for Gastroenterology where he focuses his efforts on improving the quality of gastroenterology care for Veterans, especially with respect to the quality of colonoscopy. He is also involved in crafting policy related to other aspects of care, including cancer screening, liver disease and other key healthcare issues.

Prasad Iyer, MD, FACG, FASGE

Dr. Iyer attended medical school at All India Institute of Medical Sciences in New Delhi, India. He completed his residency at the University of Wisconsin Medical School in Milwaukee, WI, and his GI Fellowship at Mayo Clinic College of Medicine, Rochester, MN, where he also completed a Postdoctoral Master’s Degree in Clinical Research. Dr. Iyer is a Consultant and Professor in the Barrett’s Esophagus Unit, Division of Gastroenterology and Hepatology at Mayo Clinic, Rochester, MN, where he has been on staff since 2006. He is a member of the Esophageal Interest Group and Advanced Endoscopy group.  Dr. Iyer is Associate Editor of Gastrointestinal Endoscopy and the Chair of the International Committee of the American Society of Gastrointestinal Endoscopy.  His clinical and research interests include early detection, risk stratification and therapy of Barrett’s related neoplasia and endoscopic ultrasound. He has published over 140 peer reviewed articles as well as several book chapters. He is a reviewer for many journals including American Journal of Gastroenterology, Clinical Gastroenterology and Hepatology and Gastrointestinal Endoscopy.

Aasma Shaukat, MD, FACG, FASGE

Dr. Shaukat is the GI Section chief at Minneapolis VAHCS and Professor of Medicine at the University of Minnesota.  Dr. Shaukat's area of clinical research is colon cancer screening and long-term outcomes. She has published her results on the long-term follow-up of the participants of the Minnesota fecal occult blood trials in NEJM and is now evaluating the age and gender specific benefits of colon cancer screening. She also studies molecular markers of rapid colon cancer growth, and studying quality indicators for colonoscopy such as adenoma detection rates and withdrawal times. She is studying the role of fecal microbiota transplant in recurrent C.difficle infection. Her other areas of research include chemoprevention for colon cancer, biomarkers of risk of colon cancer and evidence synthesis through systematic reviews and meta-analyses.


GIQuIC Research Publications

Wani S, Williams JL, Komanduri S, Muthusamy VR, Shaheen NJ. Time trends in adherence to surveillance intervals and biopsy protocol among patients with Barrett’s esophagus. Gastroenterology. 2020 Feb;158(3):770-772. Epub 2019 Oct 14.

Shaukat A, Holub J, Greenwald D, Eisen G, Schmitt C. Variation over time and factors associated with detection rates of sessile serrated lesion across the United States: Results from a national sample using the GIQuIC Registry. Am J of Gastroenterol. 2020 Aug 21. Doi: 10.14309/ajg.0000000000000824. Epub ahead of print. PMID: 32833735.

Wani S, Williams JL, Falk GW, Komanduri S, Muthusamy VR, Shaheen NJ. An analysis of the GIQuIC nationwide quality registry reveals unnecessary surveillance endoscopies in patients with normal and irregular z-lines. Am J Gastroenterol. 2020 Nov;115(11):1869-1878. doi: 10.14309/ajg.0000000000000960. PMID: 33156106.

Wani S, Williams JL, Komanduri S, Muthusamy VR, Shaheen NJ. Over-utilization of repeat upper endoscopy in patients with non-dysplastic Barrett’s esophagus: A quality registry study. Am J Gastroenterol. 2019 Aug;114(8):1256-64.

Wani S, Williams JL, Komanduri S, Muthusamy VR, Shaheen NJ. Endoscopists systematically undersample patients with long-segment Barrett's esophagus: An analysis of biopsy practices from a quality improvement registry. Gastrointest Endos. 2019 Nov;90(5):732-41.

Calderwood AH, Holub JL, Greenwald DA, Robertson DJ. Yield and practice patterns of surveillance colonoscopy among older adults: An analysis of the GI Quality Improvement Consortium. Am J of Gastroenterol, 2019 Nov;114(11):1811-19.

Peery AF, Crockett SD, Murphy CC, et al. Burden and cost of gastrointestinal, liver, and pancreatic diseases in the United States: Updated 2018. Gastroenterology. 2019 Jan;156(1):254-272.

Wallace MB, Crook JE, Thomas CS, Staggs E, Parker L, Rex DK. Effect of an endoscopic quality improvement program on adenoma detection rates: a multicenter cluster-randomized controlled trial in a clinical practice setting (EQUIP-3). Gastrointest Endosc. 2017;85(3):538-545.e4. doi:10.1016/j.gie.2016.07.042


Research FAQs

What procedure types are available?
As of October 2019, the Research Data Warehouse contains colonoscopy and EGD data.

Are the data limited to the colonoscopy and EGD quality measures for which GIQuIC reports?
No. The following links will provide you with details on the colonoscopy and EGD data collected. These fields with Protected Health Information (PHI) removed or otherwise transformed constitute the Research Data Warehouse.

Do I need an IRB?
This depends on the nature of your project. Projects that examine GIQuIC data that has been de-identified and transferred to the Research Data Warehouse are exempt from IRB overview as determined by Western IRB. Only GIQuIC staff has access to the Research Data Warehouse. A copy of the Exemption Determination Letter from Western IRB is available upon request. Projects that involve patient and/or provider contact for the collection of information not already included in the research data warehouse will require additional IRB review. This can be covered by Western IRB, or you may choose to use an IRB with which you have an affiliation (e.g. academic institution IRB).

Who performs data extraction, cleaning and analysis? Can I receive a full copy of the dataset?
All data-related tasks (extraction, cleaning, analysis) are performed in-house due to the complex nature of the dataset and the training required to use it. Results are released to investigators only in aggregate form.

Is there a cost associated with GIQuIC research?
Yes. Project costs are determined by the amount of effort required by the GIQuIC staff to complete the proposed work. The effort is based on project complexity, type of statistical analysis and other considerations. The Research staff will work with potential investigators to develop a Scope of Work for project proposals. Funding opportunities are available from numerous sources, including our sponsoring societies the ACG and ASGE.

Does my site need to contribute data to GIQuIC in order to do research?
Being a member of GIQuIC is not a requirement, however we encourage all sites to consider joining the registry, as participation in GIQuIC is one factor that is taken into consideration when determining whether or not the project can be supported.